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Biomedical Science · global

Three More Months for Drug-Resistant Metastatic Colorectal Cancer: The SUNLIGHT Trial Gives an Old Drug Combination a New Place

For patients with metastatic colorectal cancer who have already gone through multiple lines of treatment, efficacy is often measured in months. A large phase 3 trial showed that adding bevacizumab to trifluridine/tipiracil can push the limited space for later-line treatment a little further, but this is not a story of cure. It is a story of how evidence rewrites clinical options.

Biomedicine · global

Two Antibody-Drug Conjugates Signal Progress in Breast Cancer Treatment as Chemotherapy’s Role Loosens but Remains in Place

Datroway and Trodelvy have both shown an ability to delay disease worsening in clinical trials, giving some breast cancer patients the possibility of less traditional chemotherapy; the real questions remain which patients can benefit, how long the effects can last, and whether safety is sufficient to support a rewrite of treatment sequencing.